MicroCures also is developing MCR-111 as a potential treatment in the area of burn repair.
Data from preclinical studies in pig and mouse burn wound models have consistently demonstrated significantly improved and accelerated repair of burn wounds following treatment with MCR-111. MicroCures has partnered with a CMO to produce 2 GMP compatible formulations which have been tested successfully in the highly relevant porcine burn model. These siRNA delivering formulations are commercially viable to produce.
Pig Full Thickness Burn Study
Necrosis scores for MCR-111-treated subjects were dramatically lower than placebo and control subjects. This reduction in necrotic progression is believed to allow healing while preventing further deepening and expansion of the original burn wound.
The images below, taken at Week 6, provide clear visual evidence of improved would repair for siFi2-treated subjects as compared to placebo and control.
Wound Healing at Week 6
- 39% of MCR-111-treated wounds were closed as compared to only 11% for control subjects and 0% for placebo
- MCR-111-treated subjects demonstrated a significantly improved rate of repair as measured by epithelial surface measurements vs placebo (p = 0.0106) and control (p = 0.0012)
- MCR-111-treated subjects demonstrated greater enhancement in mature collagen as compared to placebo and control
Wound Healing at Week 8: Burns treated with 0.1 ml of each agent at time of injury and every third day thereafter (arrows indicate wound zones)
Mouse Full Thickness Burn Studies
When compared to control subjects, those treated with MCR-111 demonstrated:
- Reduced burn size and inflammation
- Improved epidermal thickness and structure, closely resembling unwounded skin
- Enhanced collagen deposition and hair follicle formation, closely resembling unwounded skin
- At week 2, 100% of all MCR-111-treated burns closed completely, while only 75% of placebo and 70% of control subjects had their burns completely closed
Full Thickness Burn Study in MCR-111 in Combination with PluroGel
When combined with PluroGel, a commonly used wound and burn dressing, MCR-111 resulted in statistically significant reductions in both burn wound length and burn wound epidermal thickness as compared to PluroGel alone and control. Histology images below show that the wounds treated with the MCR-111 and PluroGel combination demonstrated a structure most similar to unwounded skin.