Publications and Presentations
MicroCure’s innovative therapeutic platform and broad pipeline of novel drug candidates are built upon groundbreaking research into the fundamental nature of microtubule activity and its impact on cell movement.
Below is a sampling of scientific publications that have either contributed to or emerged from the company’s first-of-its-kind focus on controlling cell movement for therapeutic benefit:
- March 2019
Knockdown of Fidgetin Improves Regeneration of Injured Axons by a Microtubule-Based Mechanism
The Journal of Neuroscience
Matamoros, Andrew J., Veronica J. Tom, Di Wu, Yash Rao, David J. Sharp, and Peter W. Baas - March 2019
Fidgetin-Like 2 siRNA Enhances the Wound Healing Capability of a Surfactant Polymer Dressing
Advances in Wound Care
P., O’Rourke Brian, Kramer Adam H., Cao Longyue L., Inayathullah Mohammed, Guzik Hillary, Rajadas Jayakumar, Nosanchuk Joshua D., and Sharp David J. - October 2016
Targeting Microtubules for Wound Repair
Advances in Wound Care
Charafeddine, Rabab A., Joshua D. Nosanchuk, and David J. Sharp - September 2015
Fidgetin-Like 2: A Microtubule-Based Regulator of Wound Healing
Journal of Investigative Dermatology
Charafeddine, R. A., J. Makdisi, D. Schairer, B. P. O’Rourke, J. D. Diaz-Valencia, J. Chouake, A. Kutner, A. Krausz, B. Adler, P. Nacharaju, H. Liang, S. Mukherjee, J. M. Friedman, A. Friedman, J. D. Nosanchuk, and D. J. Sharp - September 2015
Vertebrate Fidgetin Restrains Axonal Growth by Severing Labile Domains of Microtubules
Cell Reports
Leo, L., W. Yu, M. D’Rozario, E. A. Waddell, D.R. Marenda, M.A. Baird, M.W. Davidson, B. Zhou, B. Wu, L. Baker, D.J. Sharp, and P.W. Baas - June 2014
Cep192 Controls the Balance of Centrosome and Non-Centrosomal Microtubules During Interphase
PLOS One
O’Rourke, B.P., M. A. Gomez-Ferreria, R.H. Berk, A. M. Hackl, M. P. Nicholas, S. C. O’Rourke, L. Pelletier, and D. J. Sharp - June 2012
Microtubule-Severing Enzymes at the Cutting Edge
Journal of Cell Science
Sharp, D. J., and J. L. Ross - April 2007
Three Microtubule Severing Enzymes Contribute to the “Pacman-Flux” Machinery that Moves Chromosomes
Journal of Cell Biology
Zhang, D., G. C. Rogers, D. W. Buster, and D. J. Sharp