Publications and Presentations

MicroCure’s innovative therapeutic platform and broad pipeline of novel drug candidates are built upon groundbreaking research into the fundamental nature of microtubule activity and its impact on cell movement.

Below is a sampling of scientific publications that have either contributed to or emerged from the company’s first-of-its-kind focus on controlling cell movement for therapeutic benefit:

• October 2021
  Understanding the role of fidgetin-like 2 in cavernous nerve growth following injury
  Dr. Lisa Baker, Invited Speaker. Basic Science Symposium at the 22nd Annual Meeting of the Sexual Medicine Society of North America.
• June 2021
  Fidgetin-like 2 negatively regulates axonal growth and can be targeted to promote functional nerve regeneration
  Journal of Clinical Investigation Insight
  Baker, L., Tar, M., Kramer, A., Villegas, G., Charafeddine, RA., Vafaeva, O., Nacharaju, P., Friedman, J., Davies, KP, and Sharp, DJ. 2021.
• March 2021
  “Harnessing the Microtubule Cytoskeleton to Promote Functional Nerve Regeneration and Repair”
  Dr. David Sharp, Invited Speaker, Gail F. Beach Lectureship Series. The Miami Project to Cure Paralysis.
• January 2021
  A Novel Therapeutic Approach to Corneal Alkaline Burn Model by Targeting Fidgetin-like 2, a Microtubule Regulator
  Translational Vision Science and Technology
  Wang J., Dey A., Kramer AH., Miao Y., Liu J., Baker, L., Zhang C., Chuck R., and Sharp DJ.
• Sept 2020
  The kinesin-8 member Kif19 alters microtubule dynamics, suppresses cell adhesion, and promotes cancer cell invasion
  BioRxiv
  Eisenberg, S., Dey, A., Birnbaum, R., Sharp, David DJ.
• July 2020
  Harnessing Cell Migration to Repair Tissue and Combat Disease
  Dr. David Sharp, Invited Speaker. 4th Annual RNAi-based Therapeutics Summit.
• March 2019
  Knockdown of Fidgetin Improves Regeneration of Injured Axons by a Microtubule-Based Mechanism
  The Journal of Neuroscience
  Matamoros, Andrew J., Veronica J. Tom, Di Wu, Yash Rao, David J. Sharp, and Peter W. Baas
• March 2019
  Fidgetin-Like 2 siRNA Enhances the Wound Healing Capability of a Surfactant Polymer Dressing
  Advances in Wound Care
  P., O’Rourke Brian, Kramer Adam H., Cao Longyue L., Inayathullah Mohammed, Guzik Hillary, Rajadas Jayakumar, Nosanchuk Joshua D., and Sharp David J.
• October 2016
  Targeting Microtubules for Wound Repair
  Advances in Wound Care
  Charafeddine, Rabab A., Joshua D. Nosanchuk, and David J. Sharp
• September 2015
  Fidgetin-Like 2: A Microtubule-Based Regulator of Wound Healing
  Journal of Investigative Dermatology
  Charafeddine, R. A., J. Makdisi, D. Schairer, B. P. O’Rourke, J. D. Diaz-Valencia, J. Chouake, A. Kutner, A. Krausz, B. Adler, P. Nacharaju, H. Liang, S. Mukherjee, J. M. Friedman, A. Friedman, J. D. Nosanchuk, and D. J. Sharp
• September 2015
  Vertebrate Fidgetin Restrains Axonal Growth by Severing Labile Domains of Microtubules
  Cell Reports
  Leo, L., W. Yu, M. D’Rozario, E. A. Waddell, D.R. Marenda, M.A. Baird, M.W. Davidson, B. Zhou, B. Wu, L. Baker, D.J. Sharp, and P.W. Baas
• June 2014
  Cep192 Controls the Balance of Centrosome and Non-Centrosomal Microtubules During Interphase
  PLOS One
  O’Rourke, B.P., M. A. Gomez-Ferreria, R.H. Berk, A. M. Hackl, M. P. Nicholas, S. C. O’Rourke, L. Pelletier, and D. J. Sharp
• June 2012
  Microtubule-Severing Enzymes at the Cutting Edge
  Journal of Cell Science
  Sharp, D. J., and J. L. Ross
• April 2007
  Three Microtubule Severing Enzymes Contribute to the “Pacman-Flux” Machinery that Moves Chromosomes
  Journal of Cell Biology
  Zhang, D., G. C. Rogers, D. W. Buster, and D. J. Sharp